Joint Ease for Arthritis: The Most Popular Formula in the East

 
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Joint Ease Formula

This formula has been used for over a thousand years in Traditional Chinese Medicine (TCM.) To this day it is perhaps the best known and most widely used Chinese herbal formula for joint pain in mainland China and Taiwan. It is used specifically for Osteoarthritis (OA), sciatica, rheumatism, rheumatoid arthritis, pain in the knees and lower back, stiff joints, herniated discs, sprains, and carpal tunnel syndrome.

This formula treats many types of body pain including lower back pain, that sciatica, ruptured discs, and knee problems. It also helps alleviate rheumatic arthritis, bone disorders, chronic osteoarthritis and any type of condition that effects the bones and muscles. It focuses primarily on the lower back and knees.

Osteoarthritis is the most common form of joint disease in human sparing no race or geographic area.  It affected 33.6% older people in the United States and the cost of artificial knee and hip replacements for severe OA were $42.3 billion in 2009. Patients with OA suffered from swelling and pain of joints, limitation of joint motion range, limitation in walking and stair climbing, and lower quality of life. The managements for OA include weight reduction, rehabilitation, and pharmacologic therapies. 


 
 
 
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NSAIDs. The most common Western medicine used in treating OA is non-steroidal anti-inflammatory drugs, Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used medications. It was recently estimated that 19.0% of U.S. adults (43.6 million) ingested aspirin at least three times a week on a chronic basis, while an estimated 12.8% (29.4 million) took NSAIDs at least three times a week for at least 3 months.

Adverse drug reactions to inflammatory drugs NSAIDs. They are responsible for 30% of hospital admissions for Adverse Drug Reactions (UK), mainly due to bleeding, heart attack, stroke, and renal damage. While these agents can be effective in treating inflammation and pain, older adults are at increased risk for adverse. NSAID use causes an estimated 41,000 hospitalizations and 3300 deaths each year among older adults. An estimated 10–20% of people taking NSAIDs experience indigestion. (Wikipedia) It’s believed that ongoing NSAIDs deplete our digestive bacteria, leaving us open to GI issues and dangers. In particular, NSAID users exhibited a different gut microbiome profile than nonusers.


Study Results Using Joint Ease Formula:

  • Lower back pain is the most common disease in orthopedic clinics world-wide. About 40% of the patients with Lower back pain are caused by disc degeneration. An increase of proinflammatory factors promoted the extracellular matrix (ECM) degradation, which is a key cause of intervertebral disc degeneration. a widely used classic formula of traditional Chinese medicine (TCM), (DHJSW formula has been proven very effective clinically in the treatment of LBP for thousands of years (18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37).

Some modern pharmacological studies have demonstrated that DHJSW formula may have effects of analgesia, immune function regulation, blood vessel dilation, anti-inflammation, and antiplatelet aggregation (20,22,23,26,39,40)  DHJSW formula inhibits the generation of SDF-1-induced human intervertebral disc proinflammatory factors and ECM degradation.

  • Osteoarthritis of the knee. Du Huo Ji Sheng Wan (DHJSW) In this trial, 200 participants with osteoarthritis of the knee were randomly given daily doses of one of the following: 75 mg non-steroidal anti-inflammatory drug tablets, versus the placebo group, 9 g Duhuo Jisheng Wan tablets. The groups were compared with respect to side-effects and effectiveness over a four-week period. Compared to the corresponding placebo groups, participants who received either Duhuo Jisheng Wan or diclofenac had significantly lower scores for pain and stiffness. DHJSW demonstrates clinically comparable efficacy to diclofenac after 4 weeks of treatment.

Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/1472-6882-4-19

  • ACL injury. If nothing is done, the ACL injury may turn into chronic ACL deficiency. Your knee may become more and more unstable and may give out more often. The abnormal sliding within the knee also can hurt cartilage. It can trap and damage the menisci in the knee and can also lead to early osteoarthritis. Very minor tears (sprains) may heal with non-surgical treatments and regenerative medicine therapy. But full ACL tears cannot be healed without surgery. If your activities do not involve making pivoting movements on the knee, physical therapy rehabilitation may be all you need. This study indicates that

DHJST exerts significant therapeutic effect on OA, through mechanisms of inhibiting chondrocytes apoptosis, and regulating the expression of VEGF, HIF-1α in chondrocytes. This provides scientific evidence for clinics to apply DHJST in treating OA.

  • Degenerative arthritis of the knee. DHJSW formula was found to be effective in the treatment of degenerative arthritis of the knee, in 68 people involved in this study. The participants indicated symptomatic improvements in pain, stiffness and physical functioning as demonstrated in the WOMAC subscale scores which began to decrease after two weeks of treatment.

  • Knee osteoarthritis. In this review of 12 studies with 982 participants for controlling knee osteoarthritis related symptoms. Based on our investigation, DHJSW formula combined with conventional Western medicine seems to be efficacious in improving total WOMAC scores in people with KOA. Also, DJD plus sodium hyaluronate injection may have a positive effect on reducing pain (VAS scores). It is recommended that DHJSW formula should be practiced for at least 4 weeks.


References

  • Evidence of Chinese herbal medicine Duhuo Jisheng decoction for knee osteoarthritis: a systematic review of randomised clinical trial.

  • Du huo Ji sheng Tang for treating osteoarthritis of the knee: a prospective clinical observation

  • ACLT-Induced Histological Degeneration in Rabbits Were Reduced by DHJST. Action Mechanisms of Du-Huo-Ji-Sheng-Tang on Cartilage Degradation in a Rabbit Model of Osteoarthritis

  • Duhuo Jisheng Decoction (DHJSD), has been proven clinically effective for Lower Back Pain. Duhuo Jisheng Decoction inhibits SDF-1-induced inflammation and matrix degradation in human degenerative nucleus pulposus cells in vitro through the CXCR4/NF-κB pathway

  • 18 – Lyu S, Ji B, Gao W, Chen X, Xie X, Zhou J . Effects of Angelicae Pubescentis and Loranthi Decotion on repairing knee joint cartilages in rats. J Orthop Surg Res 2017; 12: 189.

  • 19 – Zhang W, Wang S, Zhang R, Zhang Y, Li X, Lin Y, et al. Evidence of Chinese herbal medicine Duhuo Jisheng decoction for knee osteoarthritis: a systematic review of randomised clinical trials. BMJ Open 2016; 6: e008973.

  • 20 – Liu F, Weng X, Lin P, Zheng C, Xu H, Liu X, et al. Duhuo Jisheng decoction inhibits endoplasmic reticulum stress in chondrocytes induced by tunicamycin through the downregulation of miR-34a. Int J Mol Med 2015; 36: 1311–8.

  • 21 – Shan F, Yuan Y, Hao JD, Huang LQ . Herbal textual research on origin and development of traditional Chinese medicine “duhuo” and “qianghuo”. Zhongguo Zhong Yao Za Zhi 2014; 39: 3399–403.

  • 22 – Liu F, Liu G, Liang W, Ye H, Weng X, Lin P, et al. Duhuo Jisheng decoction treatment inhibits the sodium nitroprussiateinduced apoptosis of chondrocytes through the mitochondrialdependent signaling pathway. Int J Mol Med 2014; 34: 1573–80.

  • 23 – Wu G, Fan H, Huang Y, Zheng C, Ye J, Liu X . Duhuo Jisheng Decoctioncontaining serum promotes proliferation of interleu-kin1betainduced chondrocytes through the p16 cyclin D1/CDK4Rb pathway. Mol Med Rep 2014; 10: 2525–

  • 24 – Chen JS, Li XH, Li HT, Weng XP, Xu HF, Ye HZ, et al. Effect of water extracts from duhuo jisheng decoction on expression of chondrocyte G1 phase regulator mRNA. Zhongguo Zhong Yao Za Zhi 2013; 38: 3949–52.

  • 25 – Lai JN, Tang JL, Wang JD . Observational studies on evaluating the safety and adverse effects of traditional chinese medicine. Evid Based Complement Alternat Med 2013; 2013: 697893

  • 26 – Wu G, Chen W, Fan H, Zheng C, Chu J, Lin R, et al. Duhuo Jisheng Decoction promotes chondrocyte proliferation through accelerated G1/S transition in osteoarthritis. Int J Mol Med 2013; 32: 1001–10.

  • 27 – Zheng CS, Xu XJ, Ye HZ, Wu GW, Li XH, Huang SP, et al. Computational approaches for exploring the potential synergy and polypharmacology of Duhuo Jisheng Decoction in the therapy of osteoarthritis. Mol Med Rep 2013; 7: 1812–8.

  • 28 – Zhao J, Zha Q, Jiang M, Cao H, Lu A . Expert consensus on the treatment of rheumatoid arthritis with Chinese patent medicines. J Altern Complement Med 2013; 19: 111–8.

  • 29 – Hsieh SC, Lai JN, Chen PC, Chen CC, Chen HJ, Wang JD . Is Duhuo Jisheng Tang containing Xixin safe? A four-week safety study. Chin Med 2010; 5: 6

  • 30 – Wu YJ, Luo SF, Yang SH, Chen JY, Yu KH, See LC . Vascular response of Raynaud's phenomenon to nifedipine or herbal medication (duhuo-tisheng tang with danggui-sini tang): a preliminary study. Chang Gung Med J 2008; 31: 492–502.

  • 31 – Xie XX, Lei QH . Observation on therapeutic effect of the spreading moxibustion on rheumatoid arthritis. Zhongguo Zhen Jiu 2008; 28: 730–2.

  • 32 – Lai JN, Chen HJ, Chen CC, Lin JH, Hwang JS, Wang JD . Duhuo jisheng tang for treating osteoarthritis of the knee: a prospective clinical observation. Chin Med 2007; 2: 4.

  • 33 – Teekachunhatean S, Kunanusorn P, Rojanasthien N, Sananpanich K, Pojchamarnwiputh S, Lhieochaiphunt S, et al. Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial [ISRCTN70292892]. BMC Complement Altern Med 2004; 4: 19.

  • 34 – Guo LQ, Taniguchi M, Chen QY, Baba K, Yamazoe Y . Inhibitory potential of herbal medicines on human cytochrome P450-mediated oxidation: properties of umbelliferous or citrus crude drugs and their relative prescriptions. Jpn J Pharmacol 2001; 85: 399–408.

  • 35 – Wang Z, Su Z, Li C, Zheng H, Tan M, Wang Z . Textual study and resource investigation on traditional Chinese drugs duhuo, jiuyanduhuo and qianghuo. Zhongguo Zhong Yao Za Zhi 1995; 20: 515–7.

  • 36 – Sheng YF . Treatment of chronic Brucellosis with combined traditional Chinese medicine and Western medicine therapy. Zhongguo Zhong Xi Yi Jie He Za Zhi 1993; 13: 88–9.

  • 37 – Tanaka O, Yasuda Y, Yamasaki K, Mihashi S . Comparative study on the constituents of some Aralia species and notice of the original plants of crude drug “Duhuo”. Yakugaku Zasshi 1972; 92: 1058–60.

  • 38 – Shen X, Zheng W, Ma M, Zhang Z . The classification method of syndromes in the Bei ji qian jin yao fang (Essential Recipes for Emergent Use Worth A Thousand Gold). Zhonghua Yi Shi Za Zhi 2014; 44: 77–80.

  • 39 – Wang JY, Chen WM, Wen CS, Hung SC, Chen PW, Chiu JH . Du-Huo-Ji-Sheng-Tang and its active component Ligusticum chuanxiong promote osteogenic differentiation and decrease the aging process of human mesenchymal stem cells. J Ethnopharmacol 2017; 198: 64–72.


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