MNL GROUP

MNL Group is a Chilean company dedicated to the research and development of characterized and standardized natural extracts for application in animal and human health, through the use of advanced methods of extraction conducted at the highest level.

MNL Group S.A. is a company created in December 2010 from a spin-off of CTI HEALTH in Chile (Consortium for Technology and Research for Health) based on the initiative of entrepreneurs and scientists who strive to generate standardized natural extracts from botanical origin, focused on nutraceutical, functional foods and botanical drugs markets.

The MNL Group’s objective is to offer products with the highest quality and safety standards, that contribute to human and animal health, promoting natural components from botanical origin, with clinically proven effectiveness in the control and prevention of high impact worldwide diseases.

WHAT IS THE MAQUI BERRY?

The Maqui berry is the most potent antioxidant superfruit in the world with seven times the antioxidant qualities of acai and nine time that of goji.*

Maqui (Aristotelia chilensis) is a native berry that only grows in the wild forest of the South of Chile, consumption of the berry by indigenous Mapuche peoples dates back thousands of years.

Maqui berry is considered to be the most powerful antioxidant superfruit for being rich in polyphenols, anthocyanins, delphinidins, and other nutrients. This helps decrease free radicals, which are agents that can be highly reactive and oxidative in the body, thereby providing protection against cancer causing processes and the negative affects of aging.

The Maqui berry grows on an evergreen tree which grows 3 to 4 meters high.

It is a small edible berry between 4 to 5 mm in diameter, with a distinct and delicious dry flavor and an intense deep purple color.

A team of local collectors is responsible for harvesting the fruit, using friendly techniques with the environment and maximizing the collection process.

It is harvested between November and March, accordingly its regional localization.

(Source: US department of agriculture ORAC database, May 2010.)

CHILE

Chile is an exceptional bioclimatic island with aggressive climate conditions for plants to grow in.

Rich Chilean soils combined with a unique microclimate created by the Andes mountains and Humboldt current are also stressed by high levels of sun radiation and large variations in temperature.

Plants that grow under these conditions contain unique phytochemical profiles that are not found in any other place in the world. These plants contain 30%- 40% more health-bearing molecules than their counterparts cultivated in other regions.

The unique harvest process and bioprocessing methodology help to maintain the purity of both the plans and the fruits.

The climate improves the quality of the berries, which result in a higher concentration of antioxidants and delphinidins. Our special indigenous Maqui berries are carefully selected by hand and harvested by families of collectors from wild forests and fields in Chile who follow old traditions that have been preserved by centuries in the Mapuche Communities.

(SOURCE: INTA : National Institution of Foods and Technology, CHILE)

MAQUI BERRY

The most potent antioxidant superfruit in the world. The Secret of the Chilean Native Forest.

Maqui berries have seven times the antioxidant qualities of acai and nine time that of goji berries.

DIFFERENTIATING CAPACITY

The antioxidant qualities of foods are measured in ORAC (Oxygen Radical Absorbance Capacity) units developed by the National Institutes of Health and USDA to measure the efficacy in neutralizing degenerative and disease-causing free radicals.

The Maqui berries exhibit the highest ORAC* capacity amongst berries.

MAQUI BERRY HAS THE HIGHEST CONTENT OF DELPHINIDINS OF ALL KNOWN BERRIES

Maqui berry is one of the most power-packed berries with anthocyanins in comparison to all fruits and berries for supplemental consumption of flavonoids due it’s anthocyanin composition of 25% Cyanidins and 75% Delphinidins. Both Cyanidins and Delphinidins have been extensively researched, which have concluded its various health benefits.

Source: USDA Database for the Flavonoid Content of Selected Foods Release 3.2
Prepared by Seema Bhagwat and David B. Haytowitz September 2015

DELPHINOL®: An innovative and unique extract with exceptional anti-aging, anti-inflammatory, and antioxidant benefits

DELPHINOL® is a world class and unique extract that is produced in Anklam, a company located in Anklam, Germany

Anklam ensures that our production is GMP compliant (Good Manufacturing Procedures), which also ensures the quality and safety of our products.

The method used for DELPHINOL® production is patent protected under the MNL Group (US 14/067,066).

DELPHINOL® MAQUI BERRY EXTRACT IS SAFE

DELPHINOL® is non-mutagenic in human lymphocyte chromosome aberation test. (Intox report 2013).

DELPHINOL® is safe in acute toxicity testingdosage of 2,000 mg/kg bw per day for 14 days (RTC report 2015).

DELPHINOL® is safe in chronic toxicity testing dosages of 100-, 300- and 1000 mg/kg bw per day for 3 months, plus recovery period. (RTC report 2015).

PATENT PROTECTION

DELPHINOL® extract is obtained from the wild maqui fruit, gathered in southern Chile.

It has a standardized content of anthocyanins (35% NLT) and an astonishing level of delphinidins (25% NLT), the highest among all food ingredient currently available.
DELPHINOL® contains potent antioxidants, which act against the five most important free radicals found in the human body: peroxyls, hydroxyls, peroxynitrites, superoxide anions and other oxygen-based free radicals.

DELPHINOL® ANTIOXIDANT

DELPHINOL® EXTRACT STANDARDIZED TO ANTHOCYANINS CONTENT

Sherine Deakin, Sandra MacRury, Isobel Ford, Ian Megson2 & Derek Stewart

Plant Products and Food Quality program Scottish Crop Research Institute, Dundee, DD2 5DA 2Department of Diabetes and Cardiovascular Science,
UHI millennium Institute, Inverness, UK 3School of Medicine and Dentistry
University of Aberdeen, Aberdeen, UK.

DELPHINOL® MAQUI BERRY AS POWERFUL SOURCE FOR POTENT POLYPHENOLS

A study carried at a university in Chile compared the polyphenol content in different berries, by just preparing the juice of berries. They compared the amounts of flavonoids present in berries and also established the “total radical absorbance potency”, the latter being a similar antioxidant potency test like “ORAC”. They found that brighter berries typically bear lower flavonoid quantities than darker berries, such as the blackberry.

Researchers discovered that the maqui berry bears approximately three-times as many polyphenols than the blackberry and correspondingly has about three-fold antioxidant potency as the blackberry. Investigations such as these generated a first interest in maqui berries with regard to their health contributions.

DELPHINOL® SUPERIOR FULL-SPECTRUM ANTIOXIDANT ORAC POTENCY

Delphinol has been analysed at the Brunswick Laboratories for estimation of the total ORAC value.

The most recent ORAC testing protocol was employed, which investigates the efficacy of an antioxidant for extinguishing five different oxygen radicals.

Delphinol was shown to extinguish all five radical species and yields a total ORAC potency of 30,852 micro-mol Trolox equivalents per gram of the extract.

DELPHINOL® ANTI-INFLAMMATION

DELPHINOL® SUPERIORFULL-SPECTRUM ANTIOXIDANT ORAC POTENCY

The transcription factor nuclear factor-kB (NF-kB) is activated by oxidative stress and pro-inflammatory stimuli and controls the expression of numerous genes involved in the inflammatory response.

Dampening NF-kB activation limits the inflammatory response, which has been suggested as a potential strategy to prevent chronic inflammatory diseases.

DELPHINIDINS REPRESENT THE MOST POTENT ANTIOXIDANT ANTHOCYANINS

DELPHINOL® ANTI-INFLAMMATORY EFFECT IN VIVO MODEL

Inflammation was induced in Sprague Dawley rats using 1% carrageenan.

The diameter of the injuries were measured and calculated as the area under the curve (AUC0-6).

Reduced plantar edema (*p<0.05); this reduction was similar to that achieved with the positive control agent, diclofenac (**p<0.01).

DELPHINOL® DELPHINIDINS PROTECT SKINS CELLS FROM UVB RADIATION DAMAGE

DELPHINOL® INFLAMMAGING

SKIN ELASTICITY STUDY IN BRASIL
Skin aging is a progressive and degenerative process caused by a decrease in the physiological functions of skin tissue.
Environmental factors, such as sun exposure and pollution, as well as concomitant diseases and lifestyle negatively impact skin tissue by increasing oxidation, thus leading to a chronic inflammatory state of the skin. This skin condition is called inflammaging (Franceschi et al., Ann N Y Acad Sci. 2000 Jun;908:244-54).
Menopause is also a factor that accelerates degenerative changes in dermal collagen and thickness, resulting in the progressive loss of collagen. The highest loss (of up to 30%) is observed in the first 5 years, followed by a 1%–2% loss of collagen annually.
This study* was conducted to evaluate the impact of the intake of:
- Collagen Peptides
- Vitamin C
- Extract of Hibiscus sabdariffa (Antioxidants, Anthicyanins)
- Standardized extract Aristotelia chilensis (brand Delphinol®) (Antioxidants, Anthocyanins)

The parameter elasticity showed a mean improvement (increase in measurements) of 20.86% compared with measurements obtained at the beginning of the study in the first evaluation; this improvement was statistically significant (p = 0.001). At the 8-week evaluation, the mean improvement was 17.8%, which was also statistically significant (p = 0.022). In the final evaluation, a significant mean improvement of 39.41% was detected (p < 0.001)

Ultrasound evaluations, measurements performed in the submental area showed a mean improvement of 6.07% compared with measurements obtained at the beginning of the study in the first month; this improvement was statistically significant (p = 0.007). In the 8-week evaluation, the mean improvement was 11.32%, which was also statistically significant (p < 0.001). In the final evaluation, a significant mean improvement of 22.38% was observed (p < 0.001)

In the 4-week evaluation, the mean improvement in measurements performed in the malar area was 5.81% compared with measurements obtained at the beginning of the study in the first month; this improvement was statistically significant (p = 0.001). In the 8-week evaluation, the mean improvement was 14.69%, which was also statistically significant (p < 0.001). In the final 12-week evaluation, a significant mean improvement of 24.97% was obtained (p < 0.001)

SUBJECTIVE EVALUATION

Overall skin appearance showed that 48.4% and 90.3% noticed a moderate-to-significant improvement in the skin after 4 and 8 weeks, respectively. Identical results were also noticed after 12 weeks in the final evaluation.
Skin elasticity - 58% perceived a moderate- to-significant improvement after 4 weeks; this percentage was 83.9% at 8 weeks and 93.5% at the end of the study.
Facial skin firmness - 64.52% and 93.5% noticed a moderate-to-significant improvement after 4 and 8 weeks of treatment, respectively. Identical results were noticed after 12 weeks in the final evaluation

CONCLUSIONS

Daily intake of one sachet of this oral nutritional supplement diluted in water for 3 months significantly improves dermal thickness, skin firmness, and elasticity, with most patients noticing an overall improvement in their skin after 4 weeks of treatment, which contributed to treatment adherence and compliance.

Supplements such as the product evaluated herein (collagen, hibiscus, vit C, Delphinol®), which combine molecules with synergistic activities and promote the neutralization of harmful external stimuli, anti- inflammatory effects, and protein synthesis, are a rational and safe choice for adjuvant treatment for skin aging and chronic Inflammation.

2. PILOT STUDY IN JAPAN

In other pilot study** conducted in Japan was concluded that ingestion of Delphinol®, increases skin brightness, collagen content, and reduces skin redess. The study was a randomized double-blind placebo-controlled pilot study with Delphinol®, a maqui berry extract standardized for anthocyanins, especially delphinidins and cyanidins, in healthy japanese female subjects.

Capsules containing Delphinol® (60 mg) or placebo were orally administered to subjects aged 27 to 57 years old for eight weeks. Skin conditions [pigmentation, redness, skin tone, wrinkles, texture, oil content, water content, trans epidermal water loss (TEWL), collagen score, dermal thickness, and elasticity] were measured before and after intervention.

This study concluded that the anthocyanin- standardized maqui berry extract Delphinol® increased skin brightness and collagen content, and improved facial skin redness.

This study suggests that the daily oral intake of maqui berry extract can help maintain a healthy facial condition associated with skin aging (inflammaging).

Delphinol Supports Skin Health

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